Messages:
| ADMIN | EMDIS cord messages | ALM_REQ | Alternative phenotype | ALM_RES | Alternative result | CBR_REQ | Cord blood unit report request | CBU_DIFF | EMDIS cord messages | CBU_FULL | EMDIS cord messages |
| DONOR_CB | Match list | IDM_REQ | IDM request | IDM_RES | Result of IDM req | MARR_STAT | Donor workup status | MATCH_SUM | Summary of match run | MSG_ACK | Message acknowledgement |
| MSG_DEN | Message denial | NEW_ADD | Address to broadcast | NO_RES | Service cannot be done | PAT_STAT | Change patient status | PAT_UPD | Patient registration/update | PHEN_LIST | Phenotype list |
| REQ_CAN | Cancel of a request | RES_REM | Result reminder | RSV_REQ | Donor reserv. request | RSV_RES | Donor reserv. result | RSV_NOT | Donor reserv. | SMP_ARR | Sample arrival date |
| SMP_REQ | Sample request | SMP_RES | Sample testing result | SMP_INFO | Sample information | TXT_MSG | Text message | TYP_REQ | Typing request | TYP_RES | Result of typing |
| WARNING | Warning message | WOR_REQ | Workup request |
Detail about the register:
| HUB | Country | Registry Software | ECS Software | Sending frequency | Generating and processing of EMDIS messages | Repeat search | Matching preferences | Downtime | HLA update |
|---|---|---|---|---|---|---|---|---|---|
| AT | Austria | Prometheus | ESTER | Twice per hour | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
None | Daily update |
| AU | Australia | MatchPoint | ESTER | Every two hours, or during nightly processing, depending on message type | Continuous | Every night for all active searches | Antigen mismatches allowed at A/B/DRB1 loci; other matching preferences not implemented |
Sunday 1:00-5:00 | Twice a week, Tu and Th |
| BE | Belgium | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| BR | Brazil | PerlECS | Every morning and night | Every morning and night | Every morning | Match is 6x6 (A*,B*,DRB1*) |
Daily update | ||
| CA | Canada | SCNSS system | PerlECS | Every 5 minutes | Continuous | In real time for preliminary searches. Every week for all active searches. |
If no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ P_MATCH_AB: More than 1 antigen mismatch is not allowed P_MATCH_DR: More than 1 antigen mismatch is not allowed P_MATCH_CB: More than 2 antigen mismatches are not allowed |
Sunday 06:00 - 09:00 | Daily - for HLA nomenclature. | Quarterly - for new or deprecated alleles. |
| CE | Czech Republic - Pilsen | RDKD system | PerlECS | Once per hour | Continuous | Every night | MP supported up to 0:61:212121, otherwise: AB = 0:40:2020:CA DR = 0:60:202020:QCA |
no (occasionally during prophylaxis) | HLA weekly, MAC definitions monthly |
| CH | Switzerland | ZKRD system | PerlECS | ||||||
| CY | Cyprus | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
Daily update | |
| CZ | Czech Republic - Prague | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| DE | Germany | ZKRD system | PerlECS | Once per hour | Once per hour | Every night for searches with recent 'activity', every week for all active searches | In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:60:2020XX20XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ P_MATCH_AB: Antigen mismatches are not allowed (overall for HLA-A, -B, -DRB1) P_MATCH_DR: More than 1 antigen mismatch is not allowed (overall for HLA-A, -B, -DRB1) P_MATCH_CB: More than 2 antigen mismatches are not allowed (overall for HLA-A, -B, -DRB1) |
19:30 - 8:30 | Daily - for HLA nomenclature. | Quarterly - for new or deprecated alleles. |
| DK | Denmark - Aarhus | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| DL | India | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs up to 2 antigen MM. In case of incorrect MPs, the following defaults are used: P_MATCH_AB: 0:XX:40:2020XXXXXX/ P_MATCH_DR: 0:XX:61:2121XX21XX/ P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| DR | Germany | Prometheus | ESTER | Every 30 minutes | Every 30 minutes | Every night for preliminary searches, every week for all active searches | Matching is done using the predictive matching algorithm Hap-E Search, developed by DKMS in 2012 which is based on haplotype frequency estimations. The algorithm has been validated in the WMDA matching validation initiative. The repeat search is performed daily (overnight, German time) for all patients registered with active status. Bochtler et al., A comparative reference study for the validation of HLA‐matching algorithms in the search for allogeneic hematopoietic stem cell donors and cord blood units, HLA, 2016 |
System availability >99.5%. Downtime for new releases or maintenance are scheduled in advance and will be communicated to partners. | Daily update |
| DS | Denmark | Prometheus | ESTER | Twice per hour. | Twice per hour. | Every 2 hours for Preliminary and every 24 hours for Active searches. | MPs up to 2 antigen MM. In case of incorrect MPs, the following defaults are used: P_MATCH_AB: 0:XX:40:2020XXXXXX/, P_MATCH_DR: 0:XX:61:2121XX21XX/, P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | With every release using HLAcore |
| EN | GB - NHSBT/BBMR | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| ES | Spain | REDMO system | EPIEmdis | Every night | No | Weekly (on Monday) update of our DNA tables from the ones from BMDW | |||
| FI | Finland | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| FR | France | SYRENAD | PerlECS | Every night | Yes | ||||
| GB | GB - Anthony Nolan Trust | PerlECS | |||||||
| GL | US - Gift of Life Foundation | MatchQuest | ESTER | Twice per hour | Twice per hour | Nightly for all active searches | No | None | Monthly |
| HR | Croatia - Zagreb | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| HU | Hungary | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| IE | Irish | Prometheus | ESTER | Twice per hour | Twice per hour | Prometheus matching algorithm included in the WMDA IT Matching Validation project. Repeat search for active (ACT) patients, once a day. Repeat search for active (ACT) patients dormant for more than 100 days, once a week. |
MPs up to 2 antigen MM. In case of incorrect MPs, the following defaults are used: P_MATCH_AB: 0:XX:40:2020XXXXXX/, P_MATCH_DR: 0:XX:61:2121XX21XX/, P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| IL | Ezer Mizion | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| IT | Italy | IBMDR system | YAEP | Every early morning from Monday to Friday | No | ||||
| LT | Lithuania | Prometheus | ESTER | Twice per hour | Twice per hour | ESTER/Prometheus every day |
MPs supported up to 2 antigen MM. In case of incorrect MPs or if no MPs are provided, the following defaults are used: AB:0:XX:40:2020XXXXXX DR:0:XX:61:2121XX21XX CB:0:XX:62:2222XX22XX |
None | Daily update |
| MK | Macedonia - Skopje | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| NL | Netherlands | Prometheus | ESTER | Twice per hour | Twice per hour | every two hours | MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:A1:61:2121212121/ Default P_MATCH_CB: 0:A2:62:2222222222/ |
None | Daily update |
| NO | Norway | Prometheus | ESTER | Twice per hour | Twice per hour | every two hours | MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:A1:61:2121212121/ Default P_MATCH_CB: 0:A2:62:2222222222/ |
None | Daily update |
| PL | Poland | CRNDSiKP | Continuous | Twice per hour | Every night | No | None | Weekly | |
| RO | Romania | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| SE | Sweden | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| SG | Singapore | Prometheus | ESTER | Every 15 minutes | Every 15 minutes | Daily | Full EMDIS IP12 standards | 60 hours per annum | Quarterly (as released) |
| SI | Slovenia | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| SK | Slovakia | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| TW | Taiwan | ESTER | Every night for active patients | Yes | |||||
| US | US-NMDP | NMDP system | PerlECS | Every two hours, or during nightly processing, depending on message type | Continuous | Every night for all active searches | Antigen mismatches allowed at A/B/DRB1 loci; other matching preferences not implemented |
None | Daily |
| WA | Wales | Prometheus | ESTER | Every Month | No | ||||
| WB | Poland ALF | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |
| ZA | South Africa - SABMR | Prometheus | ESTER | Twice per hour | Twice per hour | Every night for preliminary searches, every week for all active searches |
MPs supported up to 2 antigen mismatches. In case of incorrect MPs or if no MPs are provided, the following defaults are used: Default P_MATCH_AB: 0:XX:40:2020XXXXXX/ Default P_MATCH_DR: 0:XX:61:2121XX21XX/ Default P_MATCH_CB: 0:XX:62:2222XX22XX/ |
None | Daily update |